股骨頭無(wú)菌性壞死的保守治療方法,主要是由Ficat等前人推薦的股骨頸髓芯減壓。由于其治療結(jié)果不一致,后又優(yōu)化為帶血管游離腓骨移植,或往股骨頭壞死區(qū)注射自體干細(xì)胞。法國(guó)的倡導(dǎo)者發(fā)表了長(zhǎng)期治療結(jié)果,顯示在股骨頭壞死早期治療有效,而且股骨頭仍保持圓形。
但近十年來(lái),在沒(méi)有倡導(dǎo)者的報(bào)告中,在對(duì)照研究中、有時(shí)在隨機(jī)研究中,對(duì)單純髓芯減壓提出了反對(duì)意見(jiàn)。確認(rèn)了在壞死區(qū)域再生、和穩(wěn)定的可能性。但這些技術(shù)不易運(yùn)用。細(xì)胞治療技術(shù)需要對(duì)骨髓組織進(jìn)行離心、得到富集血液細(xì)胞的小球。已經(jīng)證明該技術(shù)長(zhǎng)期有效性和安全性,應(yīng)用于年輕的、影像正常、MRI診斷股骨頭壞死的患者。但很多股骨頭軟骨分離、股骨頭塌陷的患者,除了全髖關(guān)節(jié)置換,沒(méi)有更好的選擇。
人工關(guān)節(jié)置換技術(shù)可靠,應(yīng)用氧化鋁陶瓷,隨訪(fǎng)20年以上,未發(fā)現(xiàn)磨損和骨溶解。雖然對(duì)這些年輕和活動(dòng)量大的患者,存在關(guān)節(jié)不穩(wěn)、假體周?chē)钦鄣炔l(fā)癥。
圖1 該患者39歲,花園體力勞動(dòng)者,因雙髖疼痛求診,發(fā)現(xiàn)雙側(cè)股骨頭壞死、左股骨頭塌陷。左側(cè)進(jìn)行全髖關(guān)節(jié)置換,無(wú)癥狀的右髖注射了干細(xì)胞。術(shù)后1年X線(xiàn)片顯示,右股骨頭保持圓形。
圖2 同一患者術(shù)后一年雙髖核磁,無(wú)并發(fā)癥
圖3 術(shù)后三年,右側(cè)股骨頭輕度塌陷
圖4 同一患者術(shù)后3年,核磁顯示右股骨頭壞死軟骨分離?;颊呱形椿貧w工作,坐姿活動(dòng)無(wú)疼痛;跑步或某天劇烈運(yùn)動(dòng)后感受到右腹股溝中度疼痛。他對(duì)置換一側(cè)的結(jié)果很滿(mǎn)意,想急于做右側(cè)手術(shù),以便早日恢復(fù)職業(yè)工作。
原文導(dǎo)讀
Treatments ofavascular osteonecrosis of the hip:Current treatments
Conservativetreatments for aseptic osteonecrosis of the femoral head have their ancestor inthe core decompression of the femoral neck, recommended by Ficat. Due toinconsistent results, this treatment has been optimized by either vascularizedfibular grafting, or by injecting autologous stem cells into the necrotic zone.The French promoters have published long-term results, showing efficacy in theearly stages of the disease, where the femoral head has not yet lost itssphericity. Over the last 10years, comparative studies, sometimes randomized,opposing them to simple core decompression, have been published bynon-promoters, confirming the possibility of stabilization or even regressionof necrosis area. But these techniques are not easy to implement. Cell therapyrequires treatment of marrow samples by centrifugation to obtain a pellet witha high concentration of haematopoietic cells. The now proven long-term efficacyas well as the safety of this technique make it the method of choice fortreating young patients detected at the sub-radiological stage by MRI.Unfortunately, many are seen late with detached cephalic cartilage or collapsedfemoral head and have no other option than total hip arthroplasty. Thistechnique is very reliable. With alumina ceramics, results of more than 20yearsshow the absence of wear and osteolysis, although other complications such asinstability or periprosthetic fractures may occur in these young and activepatients.
文獻(xiàn)出處:Massin P.Treatments of avascular osteonecrosis of the hip: Current treatments. Morphologie. 2021 Jun; 105(349): 120-126. doi: 10.1016/j.morpho.2020.06.003. Epub2020 Jul 8. PMID: 32653168.
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來(lái)源:304關(guān)節(jié)學(xué)術(shù)
譯者:羅殿中